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3-hydroxy-3-methylglutaryl-Coenzyme A reductase

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of at...

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Data Correlations | 1,789 studies

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Tissues category icon Normal tissues
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Vulva 100 100
Penis 96 96
Adrenal cortex 96 96
Mucosa of mouth 95 95
Adrenal gland 92 92
Esophagus 89 89
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Compounds category icon Compounds
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Rosuvastatin [inn] 100 100
Pravastatin 100 100
Lovastatin 100 100
Fluvastatin 99 99
Cerivastatin 99 99
Simvastatin 99 99
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Diseases category icon Diseases
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Encephalomyelitis 100 100
Metastasis from mali… 96 96
Chronic fatigue synd… 94 94
Toxoplasmosis 92 92
Endometrial Cancer 90 90
Injury of central ne… 89 89
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • LOX-1-dependent regulation after oxidized LDL treatment of aortic endothelial cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    This series of samples is derived from HAECT cells, and for both GFP and LOX-1 overexpressing cells includes; 0 Hr untreated (n=3), 2 Hr untreated (n=3), 2Hr OxLDL treated (n=3), 6 Hr untreated (n=3), 6 Hr OxLDL treated (n=3), 12 Hr untreated (n=3), 12 Hr OxLDL treated (n=3), 24 Hr untreated (n=3), …

    Source: NextBio Library/Cardiovascular disorders
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Associated Researchers

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Thought leaders and organizations working on research involving HMGCR.

View All Author iconAuthors
  • Russell A DeBose-Boyd
  • Lawrence Steinman
  • Jerome I Rotter
  • Sawsan Youssef
  • Ronald M Krauss
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • AstraZeneca
  • Translational Research Informatics Center, Kobe, Hyogo, Japan
  • Pfizer
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
  • University of Cologne
View All Affiliations icon Organizations
  • Children's Hospital Oakland Research Institute
  • Stanford University School of Medicine
  • Stanford University
  • University of Texas Southwestern Medical Center
  • University Roma Tre

Clinical Trials | 116 trials

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