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high-mobility group box 2
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq]
Normal tissues
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|
||
|---|---|---|---|
| B lymphoblast |
100
|
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| Superior surface of … |
86
|
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| Vermis of cerebellum |
86
|
||
| Hemisphere of cerebe… |
85
|
||
| Subdivision of nucle… |
85
|
||
| Subthalamic nucleus |
84
|
Compounds
|
|
||
|---|---|---|---|
| Sangivamycin |
100
|
||
| Grepafloxacin |
98
|
||
| Nsc188491 |
90
|
||
| Ethosuximide |
89
|
||
| Zinc03830233 |
74
|
||
| Equol |
69
|
 Individual Studies |
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|---|---|
|
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Homo sapiens
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RNA Expression
Mus musculus
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High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription.
Authors: Benoît Laurent, Voahangy Randrianarison-Huetz, Vincent Marchal, Patrick Mayeux, Isabella Dusanter-Fourt, Dominique Duménil
Blood 2010 Jan 21 -
HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.
Authors: Michal Stros, Eva Polanská, Sona Struncová, Sárka Pospísilová
Nucleic acids research 2009 Apr
Thought leaders and organizations working on research involving HMGB2.
- Northeastern University
- Aalborg University
- Scripps Research Institute
- Miami University
- Science University of Tokyo
