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high mobility group AT-hook 2

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding...

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Data Correlations | 1,333 studies

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Tissues category icon Normal tissues
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Embryo 100 100
Bronchus 97 97
Cecum 97 97
Blastocyst 96 96
Trigeminal ganglion 95 95
Zygote 94 94
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Compounds category icon Compounds
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Actinomycin D 100 100
Asiaticoside 99 99
Fhpi 98 98
U 0126 91 91
Gentamicin 90 90
Hepatocyte Growth Fa… 89 89
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Diseases category icon Diseases
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Lipomatosis 100 100
Lipoma 100 100
Uterine fibroids 99 99
Alveolar rhabdomyosa… 85 85
Papillary thyroid ca… 81 81
Anogenital human pap… 80 80
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Individual Studies

  • OMIM - Lipomatosis

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • FGF2, U0126 and SB202190 treatment in mouse cerebral cortex

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Astroglia, the star-shaped cells found throughout the central nervous system are the most numerous cell type in the brain. The astroglial response to injury, generically termed reactive astrogliosis, is classically defined by cellular hypertrophy and process extension, increased glial filament produ…

    Authors: Mandell JW

    Organization: NIH Neuroscience Microarray Consortium N…
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Associated Researchers

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Thought leaders and organizations working on research involving HMGA2.

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  • Alfredo Fusco
  • Monica Fedele
  • Giovanna Maria Pierantoni
  • Guidalberto Manfioletti
  • Paolo Chieffi
View All Affiliations icon Organizations
  • Institute of Biomedical and Clinical Science
  • University of Michigan
  • University of Southern California
  • University of Trieste
  • University of Medicine and Dentistry of New Jersey

Clinical Trials | 1 trial

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