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heart and neural crest derivatives expressed 1

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq]

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Data Correlations | 663 studies

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Tissues category icon Normal tissues
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Cecum 100 100
Appendix 98 98
Vomeronasal organ 97 97
Zygote 96 96
Embryo 95 95
Subdivision of nucle… 95 95
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Compounds category icon Compounds
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Armodafinil 100 100
Sildenafil 98 98
Acyclovir 97 97
Raloxifene 96 96
Sulindac 96 96
Atropine 95 95
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Diseases category icon Diseases
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Fasting diet 100 100
Injury of artery 86 86
Acute appendicitis 85 85
Ewing's sarcoma of b… 85 85
Acquired absent test… 84 84
Abdominothoracic neu… 84 84
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Individual Studies

  • hESCs exposure to self-renewal and differentiation compounds

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Here we present a strategy to adapt hESCs to high-throughput screening (HTS) conditions, resulting in an assay suitable for the discovery of small molecules that drive hESC self-renewal or differentiation.

    Authors: Desbordes C Sabrina, Studer Lorenz

    Organization: Memorial Sloan Kettering Cancer Center M…

  • Ki-RAS and Ha-RAS transformed Caco-2 colon cancer cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Expression analysis of Ki-RAS and Ha-RAS transformed Caco-2 cells.

    Authors: Joyce Tobias, Cantarella Daniela, Isella Claudio et al.

    Organization: Institute for Cancer Research and Treatm…
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Associated Researchers

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Thought leaders and organizations working on research involving HAND1.

View All Author iconAuthors
  • Anthony B Firulli
  • Beth A Firulli
  • D Srivastava
  • Simon J Conway
  • Thomas A Drysdale
View All Affiliations icon Organizations
  • University of Texas Southwestern Medical Center
  • Fraunhofer Institute of Toxicology and Experimental Medicine
  • Samuel Lunenfeld Research Institute
  • Childrens Health Research Institute
  • University of Calgary

Community

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