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Description: Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
Drug Type: Small Molecule; Approved
Pharmacology: Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Mechanism of Action: Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
Indication: For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Half Life: Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes
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Data Correlations | 6 studies

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Genes category icon Genes
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GNRHR 100 100
GNRHR2 100 100
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Biogroups category icon Biogroups
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Peptide GPCRs 100 100
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Individual Studies

  • Granulosa cell tumorigenesis

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Comparison of global changes in ovarian transcriptomes uniquely associated with either granulosa cell tumors or luteomas, and identification of new markers for this tumor phenotype. Luteinizing hormone hypersecreting mice studied.

    Authors: Owens GE, Keri RA, Nilson JH

    Organization: Case Western Reserve University, School …

  • Comparison of mammary glands of 16 wk old wild type and LH-overexpressing mice

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    To provide insight into early events occurring in p-53-independent hormone induced tumorgenesis, mammary glands from 16 week old LH-overexpressing mice were compared to that of wild type mice. LH-overexpressing mice display elevated levels of mammogenic hormones and consequently develop spontaneous …

    Authors: Milliken L Erin, Landis D Melissa, Whitten Ira et al.

    Organization: Case Western Reserve University Pharmaco…
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Associated Researchers

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Thought leaders and organizations working on research involving Gonadotropin Releasing Hormone.

View All Author iconAuthors
  • Robert P Millar
  • Allan E Herbison
  • Kevin Morgan
  • Fred J Karsch
  • Peter C K Leung
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Eunice Kennedy Shriver National Institute of Child Health and Human De…
  • Massachusetts General Hospital
  • National Center for Research Resources (NCRR)
  • Memorial Sloan-Kettering Cancer Center
  • Yazd Research & Clinical Center for Infertility
View All Affiliations icon Organizations
  • University of British Columbia
  • University of California
  • University of Michigan
  • Harvard University
  • University of Otago School of Medical Sciences

Clinical Trials | 184 trials

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