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general transcription factor IIIA

The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the puri...

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Data Correlations | 1,419 studies

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Tissues category icon Normal tissues
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Deltoid 100 100
Superior surface of … 100 100
Subdivision of globu… 99 99
Subthalamic nucleus 98 98
Lateral nuclear grou… 98 98
Salivary gland 98 98
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Compounds category icon Compounds
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N-formylmethionine L… 100 100
Sapphyrin 93 93
Salmonella Typhi End… 92 92
Marshall's Reagent 91 91
7alpha-hydroxytestos… 90 90
Arsenic Trioxide 89 89
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Diseases category icon Diseases
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Patau's syndrome 100 100
Disease due to Hanta… 72 72
Anomaly of chromosom… 67 67
Acute myeloid leukem… 66 66
Crush injury, multip… 64 64
Adenocarcinoma of la… 64 64
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Individual Studies

  • Formation of human memory B cells in vitro

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Determine the expression pattern of in vitro cultured human centrocytes, plasma and memory B cells.

    Authors: Kuo C Tracy, Shaffer L Arthur, Haddad Joseph et al.

    Organization: Columbia University 701 W.168th Street, …

  • Human malignant peripheral nerve sheath tumor cells infected with G207 oncolytic HSV

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Oncolytic herpes simplex viruses (oHSV) are promising anticancer therapeutics. We sought to identify alterations in gene expression during oHSV infection of human malignant peripheral nerve sheath tumor (MPNST) cells.

    Authors: Mahller Y Yonatan, Sakthivel Bhuvaneswari, Baird H William et al.

    Organization: Cincinnati Children's Hospital Medical C…
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Associated Researchers

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Thought leaders and organizations working on research involving GTF3A.

View All Author iconAuthors
  • J M Gottesfeld
  • David H Petering
  • Tristen C Weiss
  • L Howe
  • Zungyoon Yang
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • TNO Quality of Life
  • Leeds Cancer Centre at St. James's University Hospital
View All Affiliations icon Organizations
  • University of Victoria
  • Case Western Reserve University
  • University of Rochester Medical Center
  • Scripps Research Institute
  • University of Oklahoma College of Medicine

Clinical Trials | 2 trials

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Community

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