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glutathione S-transferase theta 1

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provide...

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Data Correlations | 1,357 studies

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Tissues category icon Normal tissues
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Thyroid gland 100 100
Intestine 98 98
Adrenal gland 97 97
Fetus 95 95
Cecum 93 93
Salivary gland 92 92
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Compounds category icon Compounds
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Dimaprit 100 100
SID 7980111 98 98
Adenosine Triphospha… 98 98
Cp 63956 96 96
Neurokinin B 94 94
Paf Acether 93 93
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Diseases category icon Diseases
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Adult type polycysti… 100 100
Hemorrhage 89 89
Tumor of male genita… 72 72
Squamous cell carcin… 71 71
Frontotemporal degen… 71 71
Chronic rejection of… 64 64
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Individual Studies

  • Lung cancer dataset

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies.

    Authors: Nevins JR

    Organization: Duke University IGSP 2133 CIEMAS, 101 Sc…

  • expO project: Prostate Cancer subset

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The goal of expO and its consortium supporters is to procure tissue samples under standard conditions and perform gene expression analyses on a clinically annotated set of deidentified tumor samples.

    Source: NextBio Library/Oncology
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Associated Researchers

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Thought leaders and organizations working on research involving GSTT1.

View All Author iconAuthors
  • Xavier Estivill
  • Maties Torrent
  • Jordi Julvez
  • Carmen Martínez
  • Jordi Sunyer
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • M.D. Anderson Cancer Center
  • National Taiwan University Hospital
  • Masonic Cancer Center, University of Minnesota
  • University of Campinas, Brazil
  • Duke University
View All Affiliations icon Organizations
  • Shiraz University
  • Center for Research in Environmental Epidemiology
  • University of North Carolina at Chapel Hill
  • University of Southampton
  • University of Western Australia

Clinical Trials | 15 trials

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Community

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