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glycogen synthase kinase 3 beta

Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase (see GYS1, MIM 138570). Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992 [PubMed 1333807]).[supplied by OMIM]

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Data Correlations | 1,733 studies

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Tissues category icon Normal tissues
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Dorsal striatum 100 100
Trigeminal ganglion 97 97
Vomeronasal organ 90 90
Substantia nigra 89 89
Preoptic area 87 87
Cecum 85 85
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Compounds category icon Compounds
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Sorafenib 100 100
Dimethyl Sulfoxide 85 85
Bpde 71 71
Echinomycin 67 67
Torcetrapib 65 65
Tacrolimus 59 59
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Diseases category icon Diseases
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Renal interstitial f… 100 100
Fasting diet 99 99
Anomaly of chromosom… 99 99
Acromegaly 96 96
Huntington's disease 93 93
Irritable bowel synd… 86 86
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Individual Studies

  • Antitumor efficacy of GDC-0879 involving BRAF mutational status

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    We have generated melanoma A375 cells stably expressing a shRNA construct for doxycycline-inducible knockdown of B-Raf (2 mg/ml Dox, 48h). Small molecule treatment was at 1000nM R341787, 24h.

    Source: NextBio Library/Oncology

  • Huntington's disease - Cerebellum, Caudate nucleus, Motor cortex BA4, and Prefrontal cortex BA9

    score: 9999 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite.

    Authors: Hodges Angela, Strand D Andrew, Aragaki K Aaron et al.

    Organization: Cardiff University School of Medicine Ps…
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Associated Researchers

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Thought leaders and organizations working on research involving GSK3B.

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  • Marc G Caron
  • Richard S Jope
  • Raul R Gainetdinov
  • Jean-Martin Beaulieu
  • John B J Kwok
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  • Nantes University Hospital
  • Westat
View All Affiliations icon Organizations
  • University of Alabama - Birmingham
  • Duke University Medical Center
  • University of California
  • Rockefeller University
  • Stanford University School of Medicine

Clinical Trials | 2 trials

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Community

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