NextBio

Help

gastrin-releasing peptide

This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different ...

View Gene Details



Data Correlations | 589 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
Fundus of stomach 100 100
Fetal organ 96 96
Bronchus 93 93
Ventral tegmental ar… 92 92
Cardia of stomach 91 91
Substantia nigra 91 91
View Top Normal tissues
Compounds category icon Compounds
Score Help
Vinblastine 100 100
Ethylestrenol 97 97
Vinorelbine 84 84
Methoxatin 83 83
Oxirane 81 81
Venlafaxine 77 77
View Top Compounds
Diseases category icon Diseases
Score Help
Small cell carcinoma… 100 100
Breast lobule hyperp… 94 94
Non-small cell lung … 93 93
Lymph node metastase… 93 93
Breast cancer 88 88
Deprivation of water 86 86
View Top Diseases

Individual Studies

  • Molecular signatures of mouse fetal and adult prostate stem cells

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Transcriptional profiles of four populations of cells:fetal prostate stem cells, Sca-1Hi, cells enriched in adult prostate stem cells, Sca-1Lo cells that are enriched in transit-amplifying cells, and Sca-1Neg cells with no Sca expression, that represent the most mature population.

    Source: NextBio Library/Stem Cells, Differentiation & Development

  • Diversity of gene expression in adenocarcinoma of the lung

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The expression profiles for 67 human lung tumors representing 56 patients were examined. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma.

    Authors: Garber Mitchell

    Organization: Stanford Microarray Database (SMD) Stanf…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving GRP.

View All Author iconAuthors
  • Hirotaka Sakamoto
  • Mitsuhiro Kawata
  • Lee Zou
  • Damian G Zuloaga
  • Cynthia L Jordan
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Glaxo Wellcome
  • Genentech
  • Sandoz Inc.
  • U.S. Army Office of the Surgeon General
View All Affiliations icon Organizations
  • Columbia University
  • Kyoto Prefectural University of Medicine
  • China Pharmaceutical University
  • Johns Hopkins University School of Medicine
  • Beatson Institute for Cancer Research

Clinical Trials | 84 trials

Help for Clinical Trials View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “GRP”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

  • No NextBio groups were found for “GRP”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio