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glutamate receptor, metabotropic 7
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while ...
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| Cholebrine |
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| Pantoprazole |
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| D-serine Resid… |
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| Doxapram |
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| Suprofen |
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| Gelsemine |
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| Carotid athero… |
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| Pharnyx Cancer |
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| Metastasis fro… |
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Homo sapiens
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RNA Expression
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GRM7 variants confer susceptibility to age-related hearing impairment.
Authors: Rick A Friedman, Lut Van Laer, Matthew J Huentelman, Sonal S Sheth, Els Van Eyken, Jason J Corneveaux, Waibhav D Tembe, Rebecca F Halperin, Ashley Q Thorburn, Sofie Thys,…
Human molecular genetics 2009 Feb 15 -
Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.
Authors: Young Ho Suh, Kenneth A Pelkey, Gabriela Lavezzari, Paul A Roche, Richard L Huganir, Chris J McBain, Katherine W Roche
Neuron 2008 Jun 12
Thought leaders and organizations working on research involving GRM7.
- Institute of Pharmacology
- National Institute of Child Health and Human Development
- National Institute of Neurological Disorders and Stroke
- National Institute on Drug Abuse
- Royal Adelaide Hospital
