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glutamate receptor, metabotropic 7
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while ...
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Authors: Rick A Friedman, Lut Van Laer, Matthew J Huentelman, Sonal S Sheth, Els Van Eyken, Jason J Corneveaux, Waibhav D Tembe, Rebecca F Halperin, Ashley Q Thorburn, Sofie Thys,…
Human molecular genetics 2009 Feb 15Authors: Young Ho Suh, Kenneth A Pelkey, Gabriela Lavezzari, Paul A Roche, Richard L Huganir, Chris J McBain, Katherine W Roche
Neuron 2008 Jun 12Thought leaders and organizations working on research involving GRM7.