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glutamate receptor, ionotropic, N-methyl D-aspartate 2B

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq]

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Data Correlations | 700 studies

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Tissues category icon Normal tissues
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Femur 100 100
Dorsal striatum 98 98
Shell region of nucl… 97 97
Nucleus accumbens 96 96
Putamen 94 94
Core region of nucle… 89 89
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Compounds category icon Compounds
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Loperamide 100 100
Spbio_001131 77 77
Zinc00901555 75 75
Scacchite 75 75
Convolamine, Hydroch… 73 73
Cetraxate 72 72
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Diseases category icon Diseases
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Carcinoma of urinary… 100 100
Androgen insensitivi… 97 97
House dust mite alle… 94 94
Tenosynovial giant c… 84 84
Hyperplastic polyp o… 83 83
Adenovirus infection 80 80
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Individual Studies

  • Comparison of brain regions among common laboratory mice strains

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Survey of gene expression in ten common inbred strains of laboratory mouse. Seven brain regions examined: amygdala, basal ganglia, cerebellum, frontal cortex, hippocampus, cingulate cortex, olfactory bulb.

    Authors: Nadler JJ, Zou F, Huang H et al.

    Organization: University of North Carolina Genetics Ma…

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving GRIN2B.

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  • James L Kennedy
  • Xue-Han Zhang
  • Hannah Monyer
  • Mark F Bear
  • Peter H Seeburg
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  • Mayo Clinic
  • Massachusetts General Hospital
View All Affiliations icon Organizations
  • Fudan University
  • Laboratoire de Neurobiologie
  • Howard Hughes Medical Institute
  • Stanford University
  • University of Toronto

Clinical Trials | 2 trials

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