GRIN1 - NextBio

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Search Term: GRIN1 (gene)

Overview

glutamate receptor, ionotropic, N-methyl D-aspartate 1

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq]

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Data Correlations | 986 studies

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Normal tissues

Score

Caudate nucleus

100

Thalamus

Spinal cord

Large intestine

Preoptic area

Dorsal striatum

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Compounds

Score

Orphenadrine

100

Oxybenzone

C10662

Zinc00028150

Piromidic Acid

Allyl Alcohol

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Diseases

Score

Neurofibromatosis ty…

100

Simple schizophrenia

Whipple's disease

Contusions

Pilocytic astrocytom…

Adenovirus infection

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Individual Studies
Mouse Phenotypes - Autosomal dominant hereditary disorder score: 100 \| Mus musculus \| Mutations/Phenotypic This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni… Source: NextBio Library/Mutation and Phenotypic data	Drug target sets for approved compounds score: 100 \| Homo sapiens \| Therapeutic The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. Authors: David S Wishart, Craig Knox, An Chi Guo et al. Organization: Department of Computing Science, Univers…

Individual Studies

Mouse Phenotypes - Autosomal dominant hereditary disorder

score: 100 | Mus musculus | Mutations/Phenotypic

This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

Source: NextBio Library/Mutation and Phenotypic data

Drug target sets for approved compounds

score: 100 | Homo sapiens | Therapeutic

The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

Authors: David S Wishart, Craig Knox, An Chi Guo et al.

Organization: Department of Computing Science, Univers…