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glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq]

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Data Correlations | 1,510 studies

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Tissues category icon Normal tissues
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Tongue 100 100
Skeletal muscle tiss… 97 97
Deltoid 94 94
Epidermis 94 94
Cecum 88 88
Quadriceps femoris 87 87
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Compounds category icon Compounds
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Chlorambucil 100 100
Tacrine 97 97
Ethylestrenol 96 96
Niacinamide 95 95
Isoflurophate 94 94
Scacchite 92 92
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Diseases category icon Diseases
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Chronic obstructive … 100 100
Squamous cell carcin… 88 88
Breast lobule hyperp… 83 83
Tumor of choroid ple… 79 79
Iron overload 73 73
Helicobacter-associa… 73 73
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Individual Studies

  • Liver Pharmacology and Xenobiotic Response Repertoire

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

    Authors: Natsoulis G, Pearson CI, Gollub J et al.

    Organization: Iconix Biosciences 325 E. Middlefield Rd…

  • Non-genotoxic Hepatocarcinogens (Iconix study)

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    We have developed a short-term in vivo rat assay that predicts whether non-genotoxic chemicals are likely to induce hepatic tumors based on transcript profiles in the liver. Using a large independent test set, assay accuracy was found to be superior to existing pathological and genomic markers. Comp…

    Authors: Fielden MR, Brennan R, Gollub J

    Organization: Iconix Biosciences 325 E. Middlefield Rd…
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Associated Researchers

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Thought leaders and organizations working on research involving GOT2.

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  • Mikhail V Sholukh
  • Boris I Kurganov
  • Kira A Markossian
  • Lars Kölby
  • Viktor Johanson
View All Affiliations icon Organizations
  • University of California
  • Sahlgrenska University Hospital
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • University of Florida
  • Bach Institute of Biochemistry

Clinical Trials | 2 trials

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Community

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