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glutamate dehydrogenase 1
L-glutamate dehydrogenase (EC 1.4.1.3) has a central role in nitrogen metabolism in plants and animals. Glutamate dehydrogenase is found in all organisms and catalyzes the oxidative deamination of 1-glutamate to 2-oxoglutarate (Smith et al., 2001 [PubMed 11254391]). Glutamate, the main substrate of GLUD, is present in brain in concentrations higher than in other organs. In nervous tissue, GLUD appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification (Mavrothalassitis et al., 1988 [PubMed 3368458]).[supplied by OMIM]
Normal tissues
|
|
||
|---|---|---|---|
| Caudate nucleus |
100
|
||
| Locus ceruleus |
99
|
||
| Intestine |
98
|
||
| Set of raphe nuclei |
98
|
||
| Substantia nigra |
94
|
||
| Spinal cord |
92
|
Compounds
|
|
||
|---|---|---|---|
| Diquat Dibromide |
100
|
||
| Panzem |
97
|
||
| D-galactosamine |
96
|
||
| Asparagine |
93
|
||
| L-phenylalanine |
82
|
||
| Amoxapine |
82
|
Diseases
|
|
||
|---|---|---|---|
| Hyperinsulinism |
100
|
||
| Dehydration |
72
|
||
| Starvation |
72
|
||
| Breast lobule hyperp… |
68
|
||
| Irritable bowel synd… |
66
|
||
| Streptococcal infect… |
63
|
 Individual Studies |
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|---|---|
|
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Homo sapiens
|
Mutations/Phenotypic
Rattus norvegicus
|
RNA Expression
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Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.
Authors: Fabien Burki, Henrik Kaessmann
Nature genetics 2004 Oct -
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Authors: Marcia C Haigis, Raul Mostoslavsky, Kevin M Haigis, Kamau Fahie, Danos C Christodoulou, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Margaret Karow, Gil Blander,…
Cell 2006 Sep 8
Thought leaders and organizations working on research involving GLUD1.
- Andreas Plaitakis
- Vasileios Mastorodemos
- Cleanthe Spanaki
- Ioannis Zaganas
- Konstantinos Kanavouras
- University of Crete
- Institut National de la Recherche Agronomique
- University of Crete School of Health Sciences
- Donald Danforth Plant Science Center
- University College London
