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GDNF family receptor alpha 1

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]

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Data Correlations | 926 studies

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Tissues category icon Normal tissues
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Trigeminal gan… 100 100
Preoptic area 94 94
Substantia nig… 94 94
Set of raphe n… 93 93
Spinal cord 91 91
Dorsal striatu… 90 90
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Compounds category icon Compounds
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Cyclophosphami… 100 100
Epirubicin 100 100
Tamoxifen Citr… 98 98
Orotic Acid 90 90
Nevirapine 87 87
Ethylene Dibro… 87 87
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Diseases category icon Diseases
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Congenital meg… 100 100
N3 99 99
Breast cancer 98 98
Lymph node met… 84 84
Encephalomyeli… 77 77
N2 77 77
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Individual Studies

  • Six tissues from ATGL knock-out versus wild type mice

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Gene expression profiling in 6 tissues (white adipose tissue (WAT), brown adipose tissue (BAT), cardiac muscle (CM), liver (LIV), kidney (KID), skeletal muscle (SM)) from ATGL(-/-) mice versus wildtype (ATGL+/+) mice.

    Source: NextBio Library/Metabolic disorders and Obesity

  • Gene expression signature of breast cancer following chemotherapy

    score: 9999 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Gene expression signature following neoadjuvant anthracycline-based chemotherapy of breast cancer for predicting a pathological complete response.

    Authors: Farmer P, Bonnefoi H, Iggo R

    Organization: Swiss Institute of Bioinformatics BCF Gé…
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Associated Researchers

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Thought leaders and organizations working on research involving GFRA1.

View All Author iconAuthors
  • C Eng
  • L M Mulligan
  • Marie-Claude Hofmann
  • M Takahashi
  • Martin Dym
View All Affiliations icon Organizations
  • Georgetown University Medical Center
  • Queen's University
  • Dana-Farber Cancer Institute
  • University of Illinois at Urbana-Champaign
  • Children's Medical Center of Dallas and University of Texas Southweste…

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