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gem (nuclear organelle) associated protein 4
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
Normal tissues
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|
||
|---|---|---|---|
| Caudate nucleus |
100
|
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| Interstitial cell of… |
99
|
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| Globus pallidus |
94
|
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| B lymphoblast |
93
|
||
| Vagina |
93
|
||
| Mucosa of mouth |
93
|
Compounds
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|
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|---|---|---|---|
| Triflusal |
100
|
||
| Aids081850 |
82
|
||
| Methylnitronitrosogu… |
82
|
||
| Methylergonovine |
78
|
||
| Quipazine |
73
|
||
| Cytochalasin B |
73
|
 Individual Studies |
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|---|---|
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Homo sapiens
|
RNA Expression
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Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.
Authors: Kristijan Ramadan, Roland Bruderer, Fabio M Spiga, Oliver Popp, Tina Baur, Monica Gotta, Hemmo H Meyer
Nature 2007 Dec 20 -
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Authors: Gabriela Alexandru, Johannes Graumann, Geoffrey T Smith, Natalie J Kolawa, Ruihua Fang, Raymond J Deshaies
Cell 2008 Sep 5
Thought leaders and organizations working on research involving GEMIN4.
- Max Planck Institute of Biochemistry
- Harvard Medical School
- McGill University
- University of Pennsylvania School of Medicine
- Washington University School of Medicine
Community
Graduated
University of Milan
Patrick Young
Group Leader
Stockholm University
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