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G antigen 2C
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Interstitial c… |
100
|
||
| Testis |
99
|
||
| Set of seminif… |
97
|
||
| Segment of tra… |
88
|
||
| Haploid nuclea… |
87
|
||
| Ganglion |
85
|
Compounds
|
|
||
|---|---|---|---|
| Clindamycin |
100
|
||
| 7-hydroxymetho… |
98
|
||
| Cephalothin |
98
|
||
| Decitabine |
96
|
||
| Actinomycin D |
93
|
||
| Methylatropine… |
92
|
Diseases
|
|
||
|---|---|---|---|
| Malignant tera… |
100
|
||
| Yolk sac tumor |
95
|
||
| Choriocarcinom… |
93
|
||
| Metastasis fro… |
91
|
||
| Multiple benig… |
85
|
||
| Seminoma of te… |
83
|
 Individual Studies |
|
|---|---|
|
|
Homo sapiens
|
RNA Expression
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Selective cancer-germline gene expression in pediatric brain tumors.
Authors: Joannes F M Jacobs, Oliver M Grauer, Francis Brasseur, Peter M Hoogerbrugge, Pieter Wesseling, Corrie E Gidding, Mandy W M M van de Rakt, Carl G Figdor, Pierre G Coulie, I Jolanda M de Vries,…
Journal of neuro-oncology 2008 Jul -
IFN-gamma gene transfer restores HLA-class I expression and MAGE-3 antigen presentation to CTL in HLA-deficient small cell lung cancer.
Authors: C Traversari, R Meazza, M Coppolecchia, S Basso, A Verrecchia, P van der Bruggen, A Ardizzoni, A Gaggero, S Ferrini
Gene therapy 1997 Oct
Thought leaders and organizations working on research involving GAGE2.
- Radboud University Nijmegen Medical Centre
- National Institute on Aging Intramural Research Program
- Royal Institute of Technology
