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Description: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.
Mechanism of Action: Metabolized to norfluoxetine, fluoxetine is a selective serotonin-reuptake inhibitor (SSRI), it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
Indication: For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.
Half Life: 1 to 3 days
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Data Correlations | 6 studies

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Genes category icon Genes
Score Help
SLC6A4 100 100
CA3 100 100
HSPA1B 95 95
Pbsn 94 94
DUSP11 94 94
EGR1 94 94
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Biogroups category icon Biogroups
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B Cell Receptor Complexes 100 100
Neutrophil Pathway 100 100
Basic-leucine zipper (bZIP) transcr… 99 99
Collagen helix repeat 98 98
Collagen triple helix repeat 98 98
Smooth Muscle Contraction 98 98
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Individual Studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…

  • Effect of chronic fluoxetine treatment on hippocampal gene expression

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Both the mechanism of action and the factors determining the behavioral response to antidepressants are unknown. It has been shown that antidepressant treatment promotes the proliferation and survival of hippocampal neurons via enhanced serotonergic signaling, but it is still unclear whether hippoca…

    Authors: Miller BH, Schultz LE, Gulati A et al.

    Organization: Scripps Florida 5353 Parkside Dr Jupiter…
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Associated Researchers

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Thought leaders and organizations working on research involving Fluoxetine.

View All Author iconAuthors
  • Angel Pazos
  • Elena Castro
  • Alvaro Díaz
  • Stephen N Davis
  • Donna B Tate
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Mental Health (NIMH)
  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  • Sandoz Inc.
  • FDA Office of Orphan Products Development
  • Eli Lilly and Company
View All Affiliations icon Organizations
  • Vanderbilt University
  • Duke University Medical Center
  • Texas Woman's University
  • Université Paris-Sud EA 3544
  • University of Regensburg

Clinical Trials | 565 trials

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News | 40 stories

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