NextBio

Help

Fanconi anemia (FA) is an autosomal recessive genetic disorder characterised clinically by progressive bone marrow failure, skeletal deformities and a predisposition to neoplasia. Patient cells manifest an extreme chromosomal instability and hypersensitivity to polyfunctional alkylating agents. It is assumed that the basic defect is related to the repair of DNA damage, in particular that of so-called DNA crosslinks. Currently there are eight complementation groups in FA (FA-A-FA-H) which indicates that at least eight independent genes can lead to FA. Three of these genes have been identified: FANCA, FANCC and FANCG. (from PMID 10472548)

View Complete Description



Data Correlations | 4 studies

Help for Data Correlations View All
Genes category icon Genes
Score Help
FANCA 100 100
FANCC 100 100
FANCD2 100 100
FANCM 100 100
FANCG 100 100
FANCL 100 100
View Top Genes
Biogroups category icon Biogroups
Score Help
BRCA1, BRCA2 and ATR Pathway 100 100
Stilbene Coumarine and Lignin Biosy… 97 97
Histone core 96 96
FBW7 Pathway 96 96
Ubiquinone Biosynthesis 96 96
Feeder Pathway 95 95
View Top Biogroups

Individual Studies

  • Mouse Phenotypes - Thrombocytopenia

    Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • OMIM - Congenital disorder

    Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving Fanconi's anemia.

View All Author iconAuthors
  • Alan D D'Andrea
  • Hans Joenje
  • Johan P de Winter
  • Weidong Wang
  • Amom Ruhikanta Meetei
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Masonic Cancer Center, University of Minnesota
  • Oregon Health and Science University
  • Baylor College of Medicine
  • Fred Hutchinson Cancer Research Center
View All Affiliations icon Organizations
  • Dana-Farber Cancer Institute
  • Institute of Cancer Research
  • London Research Institute
  • National Institute on Aging
  • VU University Medical Center

Clinical Trials | 116 trials

Help for Clinical Trials View All

Community

Help for Community
View All NextBio Users | 1 person
NextBio Groups

  • No NextBio groups were found for “Fanconi's anemia”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio