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FIP1 like 1 (S. cerevisiae)

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 t...

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Data Correlations | 1,346 studies

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Tissues category icon Normal tissues
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Zygote 100 100
Synovial membrane 90 90
Vermis of cerebellum 88 88
Femur 87 87
Esophagus 86 86
Cecum 85 85
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Compounds category icon Compounds
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Bovinocidin 100 100
10z,12z-octadecadien… 97 97
Beta-amylase (sweet … 96 96
Hydrogen Peroxide 96 96
Dipivefrin 96 96
Imipenem 94 94
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Diseases category icon Diseases
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Idiopathic hypereosi… 100 100
Cryptorchidism, unil… 64 64
Intestinal metaplasi… 63 63
Streptococcal pneumo… 61 61
ISM - In situ melano… 56 56
Papilloma of skin 55 55
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Individual Studies

  • Cancer census - gene mutations in cancer and other diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

    Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

    Organization: Cancer Genome Project, Human Genome Anal…

  • Chronic hypoxia effects in mouse kidney

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Chronic hypoxia alters the level, maturation and control of gene expression in mouse kidney

    Authors: Iacobas A Dumitru, Fan Chenhao, Iacobas Sanda et al.

    Organization: Albert Einstein College of Medicine Neur…
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Associated Researchers

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Thought leaders and organizations working on research involving FIP1L1.

View All Author iconAuthors
  • Jan Cools
  • Ayalew Tefferi
  • D Gary Gilliland
  • Peter Marynen
  • Jamie Robyn
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Northern Italy Leukemia Group
  • National Institute of Allergy and Infectious Diseases (NIAID)
View All Affiliations icon Organizations
  • Mayo Clinic
  • Tohoku University
  • Cincinnati Children's Hospital Medical Center
  • Brigham and Women's Hospital
  • Silesian Medical University

Clinical Trials | 2 trials

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Community

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