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fragile histidine triad gene

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. [provided by RefSeq]

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Data Correlations | 1,049 studies

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Tissues category icon Normal tissues
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Adrenal gland 100 100
Ganglion of cranial … 95 95
Vomeronasal organ 95 95
Thalamus 94 94
Globus pallidus 94 94
Salivary gland 94 94
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Compounds category icon Compounds
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P-nitrotoluene 100 100
O-methyleugenol 97 97
2-nitrotoluene 94 94
Eugenol 85 85
Amitraz 84 84
Lead Diacetate 75 75
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Diseases category icon Diseases
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Hypercholesterolemia 100 100
High fat diet 93 93
Idiopathic thrombocy… 92 92
Tumor of choroid ple… 91 91
Acute lymphocytic le… 90 90
Scarlet fever 89 89
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Individual Studies

  • Mouse Phenotypes - Skin disorder

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • Novartis 12 strain diet sex survey

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    We used microarray data set to evaluate 10 inbred strains of mice from both sexes fed atherogenic high-fat and control chow diets.

    Authors: Churchill GA, Paigen B, Shockley KR et al.

    Organization: The Jackson Laboratory Computational and…
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Associated Researchers

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Thought leaders and organizations working on research involving FHIT.

View All Author iconAuthors
  • Kay Huebner
  • Carlo M Croce
  • Teresa Druck
  • Andrea Vecchione
  • Nicola Zanesi
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Eastern Cooperative Oncology Group
  • Altor Bioscience Corporation
  • Medical University of Vienna
  • University of Colorado at Denver and Health Sciences Center
View All Affiliations icon Organizations
  • University of Parma
  • Jichi Medical University
  • University of Genoa
  • University of Texas M. D. Anderson Cancer Center
  • Ohio State University

Clinical Trials | 4 trials

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Community

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