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Fc receptor-like 3
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Superior surface of … |
100
|
||
| Zone of stomach |
94
|
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| Lymph node |
90
|
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| Cecum |
89
|
||
| Bronchus |
89
|
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| Nipple |
87
|
Compounds
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|
||
|---|---|---|---|
| Rituximab |
100
|
||
| Butyric Acid |
89
|
||
| Copolymer 1 |
74
|
||
| Staphylococcal Enter… |
70
|
||
| Methicillin |
69
|
||
| P-nitrotoluene |
69
|
 Individual Studies |
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|---|---|
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Homo sapiens
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RNA Expression
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A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.
Authors: Yuta Kochi, Ryo Yamada, Akari Suzuki, John B Harley, Senji Shirasawa, Tetsuji Sawada, Sang-Cheol Bae, Shinya Tokuhiro, Xiaotian Chang, Akihiro Sekine,…
Nature genetics 2005 May -
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.
Authors: Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Paul R Burton, David G Clayton, Lon R Cardon, Nick Craddock, Panos Deloukas, Audrey Duncanson, Dominic P Kwiatkowski, Mark I McCarthy,…
Nature genetics 2007 Nov
Thought leaders and organizations working on research involving FCRL3.
- National Institute of Arthritis and Musculoskeletal and Skin Diseases …
- University of Alabama - Birmingham
- University of Manchester
- University of Leicester
- First Affiliated Hospital of Chongqing Medical University
- Hospital Clinico San Carlos
