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F-box and WD repeat domain containing 7

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, ...

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Data Correlations | 1,403 studies

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Tissues category icon Normal tissues
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Dorsal striatum 100 100
Hemisphere of cerebe… 96 96
Nipple 96 96
Trigeminal ganglion 94 94
Substantia nigra 93 93
Globus pallidus 92 92
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Compounds category icon Compounds
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Menadione 100 100
Cytisine 81 81
Spbio_002343 70 70
4'-epidaunomycin 66 66
Somatomedin C 64 64
Sulfamerazine 64 64
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Diseases category icon Diseases
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cancer of uterus 100 100
Adult T-cell leukemi… 100 100
Tumor of gastrointes… 99 99
Neoplasm of intra-ab… 98 98
Fanconi's anemia 98 98
Post-infectious diso… 92 92
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Individual Studies

  • Cancer census - gene mutations in cancer and other diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

    Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

    Organization: Cancer Genome Project, Human Genome Anal…
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Associated Researchers

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Thought leaders and organizations working on research involving FBXW7.

View All Author iconAuthors
  • Charles Spruck
  • Olle Sangfelt
  • Keiichi I Nakayama
  • Jian-Hua Mao
  • Jesus Perez-Losada
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Eastern Cooperative Oncology Group
View All Affiliations icon Organizations
  • University of California, San Francisco
  • University of California
  • Sidney Kimmel Cancer Center
  • Stowers Institute for Medical Research
  • Kyushu University

Clinical Trials | 1 trial

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Community

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