NextBio

Help

FAT tumor suppressor homolog 1 (Drosophila)

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important ...

View Gene Details



Data Correlations | 1,280 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
Zygote 100 100
Mesenteric lymph nod… 96 96
Medulla of kidney 91 91
Segment of large int… 89 89
Spinal cord 88 88
Trigeminal ganglion 88 88
View Top Normal tissues
Compounds category icon Compounds
Score Help
Visudyne 100 100
Phorbol Ester 86 86
Human Papillomavirus… 73 73
Ethylestrenol 70 70
Bicalutamide 70 70
Methylbenzylnitrosam… 66 66
View Top Compounds
Diseases category icon Diseases
Score Help
Acute lymphoid leuke… 100 100
Hepatocellular dyspl… 94 94
Synovial sarcoma 93 93
Adult T-cell leukemi… 92 92
Malignant fibrous hi… 92 92
Congenital absence o… 86 86
View Top Diseases

Individual Studies

  • miRNA34 expression in SW480 cells

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    SW480 were stably transfected with an episomal plasmid expressing GFP and miRNA34 from a bidirectional doxycyclin regulatable promoter (Bornkamm et al Nucleic Acids Res. 2005 Sep 7;33(16)). Polyclonal cell lines were obtained by selection with Hygromycin at 350ug/ml for 10 days. The cell llnes ident…

    Authors: Bommer T Guido, Feng Ying, Kacsorowski Andrew et al.

    Organization: University of Michigan NI8D17, 300 North…

  • Molecular characterization of soft tissue tumors

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Soft-tissue tumours are derived from mesenchymal cells such as fibroblasts, muscle cells, or adipocytes, but for many such tumours the histogenesis is controversial. We aimed to start molecular characterisation of these rare neoplasms and to do a genome-wide search for new diagnostic markers.

    Authors: Van De Rijn Matt

    Organization: Stanford Microarray Database (SMD) Stanf…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving FAT.

View All Author iconAuthors
  • Bruce M Spiegelman
  • Shingo Kajimura
  • Gerald I Shulman
  • Christian Gieger
  • Gary Ruvkun
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Kythera Biopharmecuticals
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Zeltiq Aesthetics
  • University of Aarhus
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
View All Affiliations icon Organizations
  • Harvard Medical School
  • Yale University School of Medicine
  • University of California, San Diego
  • State University of New Jersey
  • University of California

Clinical Trials | 2,158 trials

Help for Clinical Trials View All

News | 1,358 stories

Help for News View All

Community

Help for Community
View All NextBio Users | 8 people
View All NextBio Groups | 2 groups

© 2010 NextBio