NextBio

Help

Ewing sarcoma breakpoint region 1

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene,...

View Gene Details



Data Correlations | 1,616 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
Subdivision of subst… 100 100
Subdivision of globu… 98 98
Subthalamic nucleus 96 96
Appendix 94 94
Pericardium 93 93
Cecum 93 93
View Top Normal tissues
Compounds category icon Compounds
Score Help
Methylnitronitrosogu… 100 100
Norethisterone 97 97
Asiaticoside 86 86
Oxolamine 82 82
Dydrogesterone 80 80
Dihydroquinine 79 79
View Top Compounds
Diseases category icon Diseases
Score Help
Ewing's sarcoma of b… 100 100
Clear cell sarcoma 100 100
Extraskeletal myxoid… 100 100
Acute lymphocytic le… 99 99
Large granular lymph… 70 70
Irritable bowel synd… 68 68
View Top Diseases

Individual Studies

  • OMIM - Malignant neoplasms

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Cancer census - gene mutations in cancer and other diseases

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

    Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

    Organization: Cancer Genome Project, Human Genome Anal…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving EWSR1.

View All Author iconAuthors
  • Ioannis Panagopoulos
  • Peter Marynen
  • Hilde Janssen
  • Fredrik Mertens
  • Lisa J Embree
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • European Organization for Research and Treatment of Cancer
  • Children's Oncology Group
View All Affiliations icon Organizations
  • National Cancer Institute
  • Sapporo Medical University School of Medicine
  • Masaryk University
  • Lund University Hospital
  • University of Leuven

News | 2 stories

Help for News View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “EWSR1”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

  • No NextBio groups were found for “EWSR1”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio