mitogen-activated protein kinase 3

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq]

Data Correlations | 1,179 studies

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Normal tissues	Score
Trigeminal ganglion	100
Cecum	99
Epidermis	87
Caudate nucleus	86
Viscerocranial mucos…	84
Spinal ganglion	83

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Compounds	Score
C14209	100
Levocabastine	99
Nicergoline	99
Meclocycline	97
Chloranol	96
Sorbitol	96

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Diseases	Score
Streptococcal pneumo…	100
cancer of hypopharyn…	100
Acquired absent test…	94
Non-secretory myelom…	94
Colitis	93
Colonic polyp	92

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Individual Studies
Kidney response to hypoxia in SS and consomic SS2BN rat strains score: 100 | Rattus norvegicus |   RNA Expression Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SS2BN) rat strain. Source: NextBio Library/Injury & Inflammation	Heart response to hypoxia in SS and consomic SS16BN rat strains score: 99 | Rattus norvegicus |   RNA Expression Transcription profiling of rat heart response to hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SS16BN) rat strain Source: NextBio Library/Metabolic disorders and Obesity

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Literature | 52,604 results

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• ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.

  Authors: Stamatia Papoutsopoulou, Antony Symons, Tharsana Tharmalingham, Monica P Belich, Frank Kaiser, Dimitris Kioussis, Anne O'Garra, Victor Tybulewicz, Steven C Ley

  Nature immunology 2006 Jun

• A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.

  Authors: Kristina Lorenz, Joachim P Schmitt, Eva M Schmitteckert, Martin J Lohse

  Nature medicine 2009 Jan

Associated Researchers

Thought leaders and organizations working on research involving ERK1.

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• Anne O'Garra
• Jacques Pouysségur
• Areez Mody
• Steven C Ley
• Sharad Ramanathan

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• Department of Veterans Affairs
• Memorial Sloan-Kettering Cancer Center
• Azienda Ospedaliera Universitaria Policlinico
• Barbara Ann Karmanos Cancer Institute
• University Medical Centre Groningen

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• University of California
• Weizmann Institute of Science
• National Institute for Medical Research
• University of Würzburg
• Case Western Reserve University

Clinical Trials | 14 trials

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• Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome

  conditions: Diabetes Mellitus, Type 2

  interventions: none

   

• Celecoxib in Treating Postmenopausal Women Who Are Undergoing Surgery for Invasive Breast Cancer

  conditions: Breast Cancer

  interventions: celecoxib ; conventional surgery ; neoadjuvant therapy

   

News | 2 stories

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• ERK1 And ERK2 Activities Are Key To Ovarian Functions And Fertility

  Medical News Today. - May 15, 2009

• Identification Of Key Proteins Needed For Ovulation

  Medical News Today. - May 15, 2009

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