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E74-like factor 5 (ets domain transcription factor)
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Salivary gland |
100
|
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| Bronchus |
91
|
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| Olfactory epithelium |
90
|
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| Vomeronasal organ |
89
|
||
| Superior surface of … |
85
|
||
| Medulla of kidney |
85
|
Compounds
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|
||
|---|---|---|---|
| Cetuximab |
100
|
||
| Azuprostat |
91
|
||
| Diamide |
90
|
||
| Gamma Rays |
89
|
||
| Cyclophosphamide |
86
|
||
| Methicillin |
82
|
 Individual Studies |
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|---|---|
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Homo sapiens
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RNA Expression
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Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.
Authors: Ray Kit Ng, Wendy Dean, Claire Dawson, Diana Lucifero, Zofia Madeja, Wolf Reik, Myriam Hemberger
Nature cell biology 2008 Nov -
The Ets transcription factor Elf5 specifies mammary alveolar cell fate.
Authors: Samantha R Oakes, Matthew J Naylor, Marie-Liesse Asselin-Labat, Katrina D Blazek, Margaret Gardiner-Garden, Heidi N Hilton, Michael Kazlauskas, Melanie A Pritchard, Lewis A Chodosh, Peter L Pfeffer,…
Genes & development 2008 Mar 1
Thought leaders and organizations working on research involving ELF5.
- Christopher J Ormandy
- Satrajit Sinha
- Matthew J Naylor
- Geoffrey J Lindeman
- Yeon Sook Choi
- State University of New York at Buffalo
- Monash University
- Garvan Institute of Medical Research
- Babraham Institute
- University of Melbourne
