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eukaryotic translation initiation factor 3, subunit K

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM]

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Data Correlations | 1,249 studies

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Tissues category icon Normal tissues
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Vermis of cerebellum 100 100
Subthalamic nucleus 87 87
Globus pallidus 87 87
Penis 86 86
Lateral globus palli… 86 86
Tongue 85 85
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Compounds category icon Compounds
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Baclofen 100 100
Alpha-ecdysone 87 87
Canavanine 80 80
Zinc Powder Or Zinc … 68 68
Dimethyl Sulfoxide 68 68
C00377 67 67
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Diseases category icon Diseases
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Pulmonary hypertensi… 100 100
Cryptorchidism 98 98
Adenocarcinoma of br… 92 92
Anomaly of chromosom… 90 90
Juvenile idiopathic … 90 90
Multiple myeloma 88 88
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Individual Studies

  • Frataxin deficiency in a Friedreich Ataxia mouse model is corrected by HDAC inhibitor

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Friedreich ataxia patients carry a GAA/TTC repeat expansion in the first intron of the frataxin gene. KIKI mice carry a (GAA)230 repeat in the first intron of the frataxin gene and have decreased frataxin levels. We treated KIKI mice with a novel histone deacetylase inhibitor, compound 106(N1-(2-ami…

    Authors: Rai Myriam, Soragni Elisabetta, Jenssen Kai et al.

    Organization: UCLA Neurology Neurogenetics 695 Charles…

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving EIF3K.

View All Author iconAuthors
  • Gerald I Shulman
  • Eun-Gyoung Hong
  • Thomas A Cooper
  • Baofeng Yang
  • Yong Zhao
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  • Northwestern University
  • Department of Defense
View All Affiliations icon Organizations
  • Technion - Israel Institute of Technology
  • Baylor College of Medicine
  • National Taiwan University
  • Ohio University
  • Ghent University

Clinical Trials | 2 trials

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Community

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