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Description: A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Mechanism of Action: Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis.
Indication: For the treatment of infections caused by susceptible organisms.
Half Life: 18-22 hours
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Data Correlations | 3 studies

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Genes category icon Genes
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TOP2A 100 100
TP53INP1 91 91
201651 90 90
TMEM132D 87 87
SDHALP1 85 85
IDH2 83 83
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Biogroups category icon Biogroups
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chr6p25 100 100
chr1p33 99 99
chr21p11 98 98
Peptidase M12B, propeptide 97 97
chr6q25 96 96
Alkaline phosphatase Protein Family 94 94
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Individual Studies

  • HTETOP cells following doxycycline or dexrazoxane treatment

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    HTETOP cells were treated with 1 µg/ml doxycycline or 100 µM dexrazoxane to inhibit TOP2A expression or vehicle for 24 hours.

    Authors: Deng Shiwei

    Organization: Uni Mainz Obere Zahlbacher Str. 67 Mainz…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving Doxycycline.

View All Author iconAuthors
  • Kenneth D Brandt
  • André Spiegel
  • Steven A Mazzuca
  • Atze T Das
  • Clay F Semenkovich
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Par Pharmaceutical, Inc.
  • Mylan Pharmaceuticals
  • University of Pittsburgh
  • Teva Pharmaceuticals USA
  • National Institute of Allergy and Infectious Diseases (NIAID)
View All Affiliations icon Organizations
  • Academic Medical Center of the University of Amsterdam
  • Whitehead Institute for Biomedical Research
  • Cambridge Institute for Medical Research
  • Leiden University Medical Center
  • Harvard Medical School

Clinical Trials | 154 trials

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Community

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