Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Adipocytes secrete a unique signalling molecule, which was named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and in...

Data Correlations | 49 studies

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Genes	Score
INS	100
WFS1	100
HNF1A	100
GCK	100
HNF1B	100
SPINK1	100

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Biogroups	Score
Ribosome	100
Antigen Processing and Presentation	99
Predicted Gene Targets for miR-1	99
Cytokine Cytokine Receptor Interact…	99
Predicted Gene Targets for miR-26	98
Predicted Gene Targets for miR-381	98

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Individual Studies
Effects of laughter in patients with type 2 diabetes Homo sapiens |   RNA Expression Peripheral blood from patients with type II diabetes before and after watching a comic video or spending tedious time. Organization: Hitachi, Ltd. Life Science Group Biotech…	Diabetic nephropathy Homo sapiens |   RNA Expression Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Authors: Baelde H, Eikmans M, Lappin D et al. Organization: LUMC Pathology Albinusdreef 2 Leiden 230…

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• Cognitive dysfunction and diabetes mellitus.

  Authors: Christopher T Kodl, Elizabeth R Seaquist

  Endocrine reviews 2008 Jun

• Neonatal diabetes mellitus.

  Authors: Lydia Aguilar-Bryan, Joseph Bryan

  Endocrine reviews 2008 May

Associated Researchers

Thought leaders and organizations working on research involving Diabetes mellitus.

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• Catherine Kim
• Assiamira Ferrara
• Shih-Jen Hwang
• Michael J Pencina
• Sarah Rosner Preis

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• Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
• Eli Lilly and Company
• Amylin Pharmaceuticals, Inc.
• Pfizer

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• University of Cambridge
• Baylor College of Medicine
• University of Michigan
• Mayo Clinic College of Medicine
• Brigham and Women's Hospital

Clinical Trials | 6,530 trials

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• Computer-Assisted Cancer Risk Behavior Counseling

  conditions: Diabetes ; Diabetes Mellitus ; Hypertension

  interventions: Health Information ; Preventive Services ; Computer tailored information

   

• Evaluation of a Diabetes Vaccine in Newly Diagnosed Diabetics

  conditions: Insulin-Dependent Diabetes Mellitus ; Diabetes Mellitus

  interventions: IBC-VS01 ; IBC-VS01 placebo

   

News | 49 stories

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• Role of Renin-Angiotensin System Blockade in Patients With Diabetes Mellitus

  American journal. - July 12, 2009

• Two-Year Results of Paclitaxel-Eluting Stents in Patients With Medically Treated Diabetes Mellitus from the TAXUS ARRIVE Program

  American journal. - April 19, 2009

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