Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Adipocytes secrete a unique signalling molecule, which was named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and in...

Data Correlations | 49 studies

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Genes	Score
INS	100
WFS1	100
HNF1A	100
GCK	100
HNF1B	100
SPINK1	100

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Biogroups	Score
Ribosome	100
Antigen Processing and Presentation	99
Predicted Gene Targets for miR-1	99
Cytokine Cytokine Receptor Interact…	99
Predicted Gene Targets for miR-26	98
Predicted Gene Targets for miR-381	98

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Individual Studies
Effects of laughter in patients with type 2 diabetes Homo sapiens |   RNA Expression Peripheral blood from patients with type II diabetes before and after watching a comic video or spending tedious time. Organization: Hitachi, Ltd. Life Science Group Biotech…	Diabetic nephropathy Homo sapiens |   RNA Expression Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Authors: Baelde H, Eikmans M, Lappin D et al. Organization: LUMC Pathology Albinusdreef 2 Leiden 230…

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• Diabetes in Asia.

  Authors: Ambady Ramachandran, Ronald Ching Wan Ma, Chamukuttan Snehalatha

  Lancet 2009 Oct 27

• Animal models of human type 1 diabetes.

  Authors: Matthias von Herrath, Gerald T Nepom

  Nature immunology 2009 Feb

Associated Researchers

Thought leaders and organizations working on research involving Diabetes.

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• Torben Hansen
• Knut Borch-Johnsen
• Oluf Pedersen
• Philippe Froguel
• Augustine Kong

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• National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
• Stanford University
• State University of New York - Upstate Medical University
• Massachusetts General Hospital
• Department of Veterans Affairs

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• University of Cambridge
• Yale University School of Medicine
• La Jolla Institute for Allergy and Immunology
• Ohio State University
• University of Iowa Carver College of Medicine

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• Childhood Diabetes

  conditions: Diabetes, Type I

  interventions: childhood diabetes

   

• Diabetes Management Personal Trainer

  conditions: Diabetes

  interventions: Managing Diabetes

   

News | 2,879 stories

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• DIABETEs

  Washington Post. - November 09, 2009

• Eight Diabetes Myths Busted

  PR-inside.com. - November 20, 2009

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