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Description: A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Dapsone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti-infective agent, it is also used for treating malaria and, recently, for Pneumocystic carinii pneumonia in AIDS patients. Dapsone is absorbed rapidly and nearly completely from the gastrointestinal tract. Dapsone is distributed throughout total body water and is present in all tissues. However, it tends to be retained in skin and muscle and especially in the liver and kidney: traces of the drug are present in these organs up to 3 weeks after therapy cessation.
Mechanism of Action: Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibiting the synthesis of dihydrofolic acid through competition with para-amino-benzoate for the active site of dihydropteroate synthetase. The anti-inflammatory action of the drug is unrelated to its antibacterial action and is still not fully understood.
Indication: For the treatment and management of leprosy and dermatitis herpetiformis.
Half Life: 28 hours (range 10-50 hours)
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Data Correlations | 37 studies

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Genes category icon Genes
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FAS 100 100
CXorf15 87 87
SNTB1 86 86
AKR1C2 85 85
ATM 85 85
PPP3R1 84 84
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Biogroups category icon Biogroups
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Natural Killer Cell Mediated Cytoto… 100 100
I8 - chymotrypsin/elastase inhibit… 97 97
Glycosphingolipid Biosynthesis Lact… 96 96
Blood Group Glycolipid Biosynthesis… 96 96
G-alpha-Q Pathway 95 95
Thiamine Metabolism 95 95
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Individual Studies

  • Peripheral neuropathies from PMP22 mutants

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    We compared gene expression at ages P4 and P60 in sciatic nerve of wild type mice and mice with peripheral neuropathies caused by altered Pmp22 gene dosage (homozygous knockout or transgene) or a point mutation (Trembler).

    Authors: Giambonini-Brugnoli G, Buchstaller J, Sommer L et al.

    Organization: Swiss Federal Institute of Technology In…

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…
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Associated Researchers

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Thought leaders and organizations working on research involving Dapsone.

View All Author iconAuthors
  • Piyush M Vyas
  • Camilo Ríos
  • Timothy S Tracy
  • Sanjoy Roychowdhury
  • Craig K Svensson
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Allergan
  • Jacobus Pharmaceutical
  • Gilead Sciences
  • Gates Malaria Partnership
View All Affiliations icon Organizations
  • London School of Hygiene and Tropical Medicine
  • University of Minnesota
  • University of Iowa
  • Wayne State University
  • University of California, San Francisco

Clinical Trials | 162 trials

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