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dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq]

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Data Correlations | 1,142 studies

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Tissues category icon Normal tissues
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Pylorus 100 100
Cecum 99 99
Deltoid 96 96
Great saphenous vein 96 96
Trigeminal ganglion 94 94
Uterine tube 93 93
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Compounds category icon Compounds
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Austricin 100 100
Homatropine 85 85
Sulfadiazine 80 80
Gabapentin 75 75
Aminohippuric Acid 74 74
Adiphenine 74 74
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Diseases category icon Diseases
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Aseptic necrosis of … 100 100
Single coronary vess… 99 99
Acute gastric mucosa… 96 96
Helicobacter pylori … 87 87
Erythema nodosum lep… 87 87
Pulmonary sarcoidosi… 78 78
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Individual Studies

  • Helicobacter positive and negative human gastritis samples

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Using microarrays we compared the whole genome gene expression profile of HP+ and HP- gastric erosions and normal adjacent mucosa to explain the possible role and response to HP infection and to get morphology related mRNA expression patterns.

    Source: NextBio Library/Immune response and infection

  • Broad Connectivity Map (CMAP 2.0) compound database

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving DYRK2.

View All Author iconAuthors
  • Kiyotsugu Yoshida
  • Noriko Murakami
  • Walter Becker
  • Mo-Chou Chen-Hwang
  • Yu-Wen Hwang
View All Affiliations icon Organizations
  • Tokyo Medical and Dental University
  • New York State Institute for Basic Research in Developmental Disabilit…
  • University of Dundee
  • Institut für Pharmakologie und Toxikologie
  • University of Texas Southwestern Medical Center

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