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dopamine receptor D2
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq]
Diseases
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|---|---|---|---|
| Extrapyramidal disor… |
100
|
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| Streptococcal pneumo… |
99
|
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| Injury to nerve duri… |
90
|
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| Alzheimer's disease |
83
|
||
| Pseudopelade |
78
|
||
| Seminoma of testis |
76
|
Gene perturbations
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|
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|---|---|---|---|
| MMP14 gene |
100
|
||
| HD gene |
99
|
||
| AHI1 gene |
98
|
||
| ADRB3 gene |
96
|
||
| FLT1 gene |
92
|
||
| MYOC gene |
91
|
Compounds
|
|
||
|---|---|---|---|
| Cabergoline |
100
|
||
| Bromocriptine |
99
|
||
| Domperidone |
98
|
||
| Remoxipride |
98
|
||
| Ropinirole |
98
|
||
| Aripiprazole |
98
|
 Individual Studies |
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|---|---|
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Homo sapiens
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Therapeutic
Mus musculus
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RNA Expression
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Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
Authors: Eric Stice, Sonja Yokum, Cara Bohon, Nate Marti, Andrew Smolen
NeuroImage 2010 May 1 -
Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan.
Authors: S J Glatt, S V Faraone, J A Lasky-Su, T Kanazawa, H-G Hwu, M T Tsuang
Molecular psychiatry 2009 Sep
Thought leaders and organizations working on research involving DRD2.
- Hadassah Medical Organization
- Centre for Addiction and Mental Health
- National Taiwan University Hospital
- Vanderbilt University
- M.D. Anderson Cancer Center
- Yale University School of Medicine
- University of Heidelberg
- University of Bonn
- University College London
- Radboud University of Nijmegen
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PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration
conditions: Smoking
interventions: Bupropion
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Dopamine and Insulin Resistance
conditions: Obesity ; Post-Menopause
interventions: PET scan ; Oral glucose tolerance test ; MRI ; Muscle/fat biopsy ; Psychological scales to assess attitudes and behaviors related to eating and quality of life
Community
Gabriela Novak
Postdoctoral Fellow
University of Toronto
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