NextBio

Help

DNA (cytosine-5-)-methyltransferase 1

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

View Gene Details



Data Correlations | 1,536 studies

Help for Data Correlations View All
Tissues category icon Normal tissues
Score Help
Mesenteric lymph nod… 100 100
Femur 99 99
Oocyte 96 96
B lymphoblast 93 93
Autonomic ganglion 93 93
Trigeminal ganglion 92 92
View Top Normal tissues
Compounds category icon Compounds
Score Help
Torasemide 100 100
Thioguanine 98 98
Citalopram 96 96
Amlodipine 94 94
Tocainide 94 94
Sulfadoxine 94 94
View Top Compounds
Diseases category icon Diseases
Score Help
SAIDS 100 100
Tularemia 98 98
Infection by Aspergi… 96 96
Human immunodeficien… 96 96
Neuroendocrine carci… 91 91
Plasma cell leukemia 88 88
View Top Diseases

Individual Studies

  • Liver Pharmacology and Xenobiotic Response Repertoire

    score: 100100 | Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

    Authors: Natsoulis G, Pearson CI, Gollub J et al.

    Organization: Iconix Biosciences 325 E. Middlefield Rd…

  • cJun dominant negative effects on lipid homeostasis

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    cJun is a transcription factor activated by phosphorylation by SAPK/JNK MAP kinase pathway that has been linked to atherosclerosis. Adenovirus mediated gene transfer of a dominant negative form of cJun in C57BL/6 mice increased greatly the apolipoprotein E (ApoE) mRNA and plasma apoE levels and indu…

    Authors: Drosatos K, Sanoudou D, Kypreos K et al.

    Organization: Foundation for Biomedical Research, Acad…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving DNMT1.

View All Author iconAuthors
  • Kam-wing Jair
  • Kornel E Schuebel
  • Sriharsa Pradhan
  • En Li
  • Stephen B Baylin
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Utah
  • Cancer and Leukemia Group B
  • Manhattan Psychiatric Center
  • National Cancer Institute (NCI)
  • Arthur G. James Cancer Hospital & Richard J. Solove Research Institute
View All Affiliations icon Organizations
  • Johns Hopkins University School of Medicine
  • Ohio State University
  • Novartis Institutes for Biomedical Research
  • Lovelace Respiratory Research Institute
  • Johns Hopkins University

Clinical Trials | 8 trials

Help for Clinical Trials View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “DNMT1”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

View All NextBio Groups | 1 group

© 2010 NextBio