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DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined. [provided by RefSeq]
Diseases
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|---|---|---|---|
| Congenital absence o… |
100
|
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| Pulmonary hypertensi… |
97
|
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| Gonorrhea |
83
|
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| Effects of heat |
83
|
||
| Dehydration |
79
|
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| Complex V deficiency |
69
|
Gene perturbations
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|
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|---|---|---|---|
| SP3 gene |
100
|
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| NPC1 gene |
56
|
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| KLF4 gene |
55
|
||
| SOX2 gene |
53
|
||
| T(16;17)43H gene |
50
|
||
| EIF2AK3 gene |
49
|
Compounds
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|
||
|---|---|---|---|
| Oxaprozin |
100
|
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| Gabapentin |
91
|
||
| Salsolinol |
89
|
||
| Xamoterol |
88
|
||
| Iopromide |
88
|
||
| Sulfasalazine |
88
|
 Individual Studies |
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|---|---|
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Mus musculus
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Mutations/Phenotypic
RNA Expression
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Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.
Authors: Roberto J Pezza, Oleg N Voloshin, Filip Vanevski, R Daniel Camerini-Otero
Genes & development 2007 Jul 15 -
Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.
Authors: Michael G Sehorn, Stefan Sigurdsson, Wendy Bussen, Vinzenz M Unger, Patrick Sung
Nature 2004 May 27
Thought leaders and organizations working on research involving DMC1.
- Yale University School of Medicine
- University of Chicago
- Osaka University
- Yale University
- Stony Brook University
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A positive but complex association between meiotic double-strand break hotspots and open chromatin in Saccharomyces cerevisiae [RESEARCH]
Genome Research. - October 02, 2009
