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dicer 1, ribonuclease type III
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Superior vena cava |
100
|
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| Inferior ganglion of… |
97
|
||
| Vermis of cerebellum |
94
|
||
| Vulva |
92
|
||
| Nipple |
87
|
||
| Zygote |
85
|
Compounds
|
|
||
|---|---|---|---|
| Levcycloserine |
100
|
||
| Selenomethionine |
85
|
||
| Fluorouracil |
83
|
||
| Procyanidin |
82
|
||
| Vitamin E |
82
|
||
| Mptp |
82
|
 Individual Studies |
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|---|---|
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Homo sapiens
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RNA Expression
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A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Authors: Sonia A Melo, Santiago Ropero, Catia Moutinho, Lauri A Aaltonen, Hiroyuki Yamamoto, George A Calin, Simona Rossi, Agustin F Fernandez, Fatima Carneiro, Carla Oliveira,…
Nature genetics 2009 Mar -
Dicer1 functions as a haploinsufficient tumor suppressor.
Authors: Madhu S Kumar, Ryan E Pester, Cindy Y Chen, Keara Lane, Christine Chin, Jun Lu, David G Kirsch, Todd R Golub, Tyler Jacks
Genes & development 2009 Dec 1
Thought leaders and organizations working on research involving DICER1.
- Scripps Research Institute
- Gunma University
- National Cancer Center Research Institute
- Rockefeller University
- University of Kansas Medical Center
