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dihydrofolate reductase

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq]

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Data Correlations | 1,776 studies

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Tissues category icon Normal tissues
Score Help
Inferior ganglion of… 100 100
Superior vena cava 99 99
Pericardium 98 98
Synovial membrane 97 97
Cardia of stomach 97 97
Subthalamic nucleus 97 97
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Compounds category icon Compounds
Score Help
Tmq 100 100
Pemetrexed 100 100
D-amethopterin 100 100
Methotrexate 67 67
Levodopa 61 61
Cefotaxime 56 56
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Diseases category icon Diseases
Score Help
Anemia 100 100
Hypoxia 100 100
Gram positive septic… 98 98
Acute lymphoid leuke… 95 95
Metastasis from mali… 95 95
Other Gram-negative … 94 94
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving DHFR.

View All Author iconAuthors
  • Amy C Anderson
  • Dennis L Wright
  • Kathleen M Frey
  • David B Bolstad
  • Rudolf K Allemann
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Cape Town
  • Gates Malaria Partnership
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • North Central Cancer Treatment Group
  • Mayo Clinic
View All Affiliations icon Organizations
  • University of Connecticut
  • Scripps Research Institute
  • Cardiff University
  • Pennsylvania State University
  • University of Virginia School of Medicine

Clinical Trials | 31 trials

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Community

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