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dopa decarboxylase (aromatic L-amino acid decarboxylase)

The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]

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Data Correlations | 1,321 studies

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Tissues category icon Normal tissues
Score Help
Cortex of kidney 100 100
Substantia nigra 100 100
Set of raphe nuclei 92 92
Ventral tegmental ar… 85 85
Cecum 85 85
Small intestine 81 81
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Compounds category icon Compounds
Score Help
Carbidopa 100 100
4-aminosalicylic Aci… 59 59
Benzo[a]pyrene 56 56
Cadmium, Isotope Of … 53 53
Epitestosterone 45 45
8-aminohexylamino-ad… 42 42
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Diseases category icon Diseases
Score Help
Deficiency of aromat… 100 100
Adult type polycysti… 66 66
Pseudopelade 65 65
Parkinson disease 63 63
Renal cell carcinoma 61 61
Benign neoplasm of r… 58 58
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Individual Studies

  • Drug target sets for approved compounds

    score: 100100 | Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • OMIM - Specific enzyme deficiency

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving DDC.

View All Author iconAuthors
  • Jun Li
  • Samuel W French
  • Fawzia Bardag-Gorce
  • Joan Oliva
  • Emmanuel G Fragoulis
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Hoffmann-La Roche
  • Glaxo Wellcome
  • Bristol-Myers Squibb
  • Gilead Sciences
View All Affiliations icon Organizations
  • University of Athens
  • Harbor-UCLA Medical Center
  • University of Alberta
  • King's College London
  • Kurume University School of Medicine

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