A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement. --2004

Data Correlations | 10 studies

View All

Genes	Score
DEFB4	100
NOD2	100
IL23R	100
STAT3	100
SLC22A4	100
RUNX3	100

View Top Genes

Biogroups	Score
chr4q21	100
Small chemokine, interleukin-8-like	99
Cytokine Cytokine Receptor Interact…	99
All Peptidase Inhibitors	99
Predicted Gene Targets for miR-23	98
Complement and Coagulation Cascades	98

View Top Biogroups

Individual Studies

Genome-wide gene expression differences between Crohn’s and ulcerative Homo sapiens |   RNA Expression Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features and complex pathophysiologies. To identify pathogenic processes underlying these disease subtypes, using single endoscopic pinch biopsies to estabolish 36 expression pr… Authors: Wu Feng, Dassopoulos Themistocles, Cope Leslie et al. Organization: Johns Hopkins University School of Medic…

Expression profiling in inflammatory bowel disease Homo sapiens |   RNA Expression The series was designed to identify new genes involved in the pathophysiology of inflammatory bowel disease (Crohn's disease and ulcerative colitis). Authors: Costello M Christine, Mah Nancy, Häsler Robert et al. Organization: University Clinic of Schleswig Holstein …

View All Individual Studies

Literature | 31,613 results

View All

• Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

  Authors: Alexandra-Chloé Villani, Mathieu Lemire, Geneviève Fortin, Edouard Louis, Mark S Silverberg, Catherine Collette, Nobuyasu Baba, Cécile Libioulle, Jacques Belaiche, Alain Bitton,…

  Nature genetics 2009 Jan

• The genetics of Crohn's disease.

  Authors: Johan Van Limbergen, David C Wilson, Jack Satsangi

  Annual review of genomics and human genetics 2009

Associated Researchers

Thought leaders and organizations working on research involving Crohn's disease.

View All Authors

• Paul Rutgeerts
• Jack Satsangi
• Natalie J Prescott
• Clive M Onnie
• Christopher G Mathew

View All Clinical Trials Sponsors

• National Institute of Allergy and Infectious Diseases (NIAID)
• Elan Pharmaceuticals
• Nationwide Children's Hospital
• Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
• Tel-Aviv Sourasky Medical Center

View All Organizations

• Children's Hospital of Philadelphia
• University of Oxford
• Christian-Albrechts-University
• University of Toronto
• Mayo Clinic

Clinical Trials | 938 trials

View All

• A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease

  conditions: Crohn's Disease

  interventions: Crohn's Disease

   

• Vitamin D Treatment for Crohn´s Disease

  conditions: Crohns Disease

  interventions: Vitamin D

   

News | 117 stories

View All

• Gene Discovery Gives Clues to Crohn's Disease, Colitis news

  e-Healthcare.

• Toward An Explanation For Crohn's Disease?

  Science Daily. - July 19, 2009

Community

NextBio Users

• No NextBio users were found for “Crohn's disease”.
  Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

• No NextBio groups were found for “Crohn's disease”.
  Be the first to start a group and share your interests with others within the NextBio community.

search → result

search → result