A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement. --2004

Data Correlations | 11 studies

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Genes	Score
DEFB4	100
NOD2	100
SLC22A4	100
IL23R	100
GPX2	100
STAT3	100

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Biogroups	Score
Cytokine Cytokine Receptor Interact…	100
All Peptidase Inhibitors	100
Small chemokine, interleukin-8-like	100
Complement and Coagulation Cascades	99
Hematopoietic Cell Lineage	98
Complement control module	97

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Individual Studies

Mouse Phenotypes - Inflammatory disorder of digestive tract Mus musculus |   Mutations/Phenotypic This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni… Source: NextBio Library/Mutation and Phenotypic data

Biopsies from the descending colon of Crohns disease patients Homo sapiens |   RNA Expression Authors: Csillag C, Nielsen OH, Olsen J Organization: University of Copenhagen Department of M…

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Literature | 31,584 results

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• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

  Authors: Jeffrey C Barrett, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada,…

  Nature genetics 2008 Aug

• Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

  Authors: Alexandra-Chloé Villani, Mathieu Lemire, Geneviève Fortin, Edouard Louis, Mark S Silverberg, Catherine Collette, Nobuyasu Baba, Cécile Libioulle, Jacques Belaiche, Alain Bitton,…

  Nature genetics 2009 Jan

Associated Researchers

Thought leaders and organizations working on research involving Crohn's disease.

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• Jack Satsangi
• Paul Rutgeerts
• Natalie J Prescott
• Clive M Onnie
• Christopher G Mathew

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• National Institute of Allergy and Infectious Diseases (NIAID)
• Elan Pharmaceuticals
• Nationwide Children's Hospital
• Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
• Tel-Aviv Sourasky Medical Center

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• University of Oxford
• Children's Hospital of Philadelphia
• Christian-Albrechts-University
• University of California
• Mayo Clinic

Clinical Trials | 938 trials

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• A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease

  conditions: Crohn's Disease

  interventions: Crohn's Disease

   

• Vitamin D Treatment for Crohn´s Disease

  conditions: Crohns Disease

  interventions: Vitamin D

   

News | 159 stories

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• Vitamin D supplements could fight Crohn's disease

  Eurekalert Cancer. - January 26, 2010

• Health Tip: Understanding Crohn's Disease news

  e-Healthcare.

Community

View All NextBio Users | 3 people

• fabio  callini

• Michael  Fromm

NextBio Groups

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