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cytochrome P450, family 2, subfamily D, polypeptide 6

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized ...

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Data Correlations | 1,080 studies

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Tissues category icon Normal tissues
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Set of raphe nuclei 100 100
Locus ceruleus 95 95
Spinal cord 91 91
Substantia nigra 91 91
Large intestine 90 90
Preoptic area 89 89
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Compounds category icon Compounds
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Niridazole 100 100
Ajmaline 90 90
Midodrine 88 88
Lysuride 88 88
Sulfabenzamide 80 80
Anabasine 78 78
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Diseases category icon Diseases
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Propensity to advers… 100 100
Parkinsonism 99 99
Infectious colitis 99 99
Hepatitis 94 94
Papilloma of skin 94 94
Liver carcinoma 93 93
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Individual Studies

  • OMIM - Propensity to adverse reactions to drug

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • OMIM - Movement disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving CYP2D6.

View All Author iconAuthors
  • Adrián LLerena
  • Shu-Feng Zhou
  • Eva M Peñas-LLedó
  • Pedro Dorado
  • S Asimus
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • AstraZeneca
  • Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
  • Wyeth
  • Pfizer
  • Assaf-Harofeh Medical Center
View All Affiliations icon Organizations
  • University of Manchester
  • Hospital Universitario Infanta Cristina
  • RMIT University
  • University of Michigan Medical School
  • Korea University College of Medicine

Clinical Trials | 163 trials

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Community

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