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cytochrome P450, family 2, subfamily C, polypeptide 9

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromos...

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Data Correlations | 933 studies

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Tissues category icon Normal tissues
Score Help
Pylorus 100 100
Cardia of stomach 97 97
Viscerocranial mucos… 96 96
Superior cervical ga… 95 95
Appendix 91 91
Esophagus 91 91
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Compounds category icon Compounds
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Tert-butoxypropanol 100 100
Nafenopin 78 78
Insulin (jp15/usp) 78 78
Benzene 76 76
Endopancrine 74 74
Mifepristone 66 66
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Diseases category icon Diseases
Score Help
Liver carcinoma 100 100
Hypoxia 92 92
Viral hepatitis 91 91
High fat diet 90 90
Primary malignant cl… 86 86
Grade 1 chronic reje… 81 81
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Individual Studies

  • Hfe-deficient liver and duodenum with differing susceptibilities to iron loading

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Hfe disruption in the mouse leads to experimental hemochromatosis by a mechanism which remains elusive. Evidence for at least five modifier genes has been obtained. These account for the higher iron load of Hfe-deficient D2 mice compared to B6 mice. Gene expression profling was used to clarify the m…

    Authors: Roth M, Coppin H

    Organization: Inserm U563 Génétique Chu Purpan Toulous…

  • Hepatocytes from hyperglycaemic obese mice fed a high fat diet

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Transcription profiling of hepatocytes from mice that are hyperglycaemic, obese and insulin resistant as a result of being fed a high fat diet

    Source: NextBio Library/Metabolic disorders and Obesity
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Associated Researchers

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Thought leaders and organizations working on research involving CYP2C9.

View All Author iconAuthors
  • Allan E Rettie
  • Marie M Ahlström
  • Charles W Locuson
  • Mark J Rieder
  • Anders Rane
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Hadassah Medical Organization
  • National Taiwan University Hospital
  • AstraZeneca
  • Intermountain Health Care, Inc.
  • University of Kansas
View All Affiliations icon Organizations
  • University of Washington
  • University of Minnesota
  • Mount Sinai School of Medicine of New York University
  • Jilin University
  • Vanderbilt University School of Medicine

Clinical Trials | 90 trials

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