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cytochrome P450, family 17, subfamily A, polypeptide 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphrod...

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Data Correlations | 732 studies

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Tissues category icon Normal tissues
Score Help
Adrenal gland 100 100
Adrenal cortex 98 98
Lymph node 58 58
Cortex of kidney 56 56
Caudate nucleus 53 53
Interstitial cell of… 53 53
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Compounds category icon Compounds
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Azamun [czech] 100 100
Otoline 96 96
Cddo-im 95 95
Celecoxib 83 83
Oltipraz 81 81
Crystal Violet 81 81
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Diseases category icon Diseases
Score Help
Deficiency of steroi… 100 100
Abdominothoracic neu… 71 71
Adrenal neuroblastom… 71 71
High fat diet 58 58
Caloric restriction … 49 49
Scarlet fever 49 49
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Individual Studies

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Normal tissues transcriptome_Hs: Relative gene expression

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Here, we have generated and analyzed gene expression from a set of samples spanning a broad range of biological conditions. Specifically, we profiled gene expression from 91 human samples across a diverse array of tissues, organs, and cell lines.

    Authors: Su AI, Cooke MP, Ching KA et al.

    Organization: Genomics Institute of the Novartis Resea…
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Associated Researchers

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Thought leaders and organizations working on research involving CYP17A1.

View All Author iconAuthors
  • Melissa C Southey
  • Alan J Conley
  • Sun Meili
  • Christa E Flück
  • Andrea A Tesoriero
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Cougar Biotechnology, Inc.
  • National Cancer Institute (NCI)
  • National Taiwan University Hospital
View All Affiliations icon Organizations
  • University of California
  • National Cancer Institute
  • University Children's Hospital Bern
  • University of California, San Francisco
  • University of Melbourne

Clinical Trials | 5 trials

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Community

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