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cytochrome c, somatic
This gene encodes cytochrome c, a component of the electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the b-c1 complex and transfers electrons to the cytochrome oxidase complex. Cytochrome c is also involved in initiation of apoptosis. Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Many cytochrome c pseudogenes exist, scattered throughout the human genome. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Cervix of uter… |
100
|
||
| Small intestin… |
97
|
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| Duodenum |
97
|
||
| Uterine tube |
90
|
||
| Deltoid |
90
|
||
| Myometrium |
88
|
Compounds
|
|
||
|---|---|---|---|
| Hydroxyzine |
100
|
||
| Irbesartan |
92
|
||
| Nitrogen |
89
|
||
| Methyl Mesylat… |
89
|
||
| Sulfur |
88
|
||
| Sampangine |
86
|
Diseases
|
|
||
|---|---|---|---|
| Acute myelomon… |
100
|
||
| Acute myeloid … |
87
|
||
| Nutrient restr… |
86
|
||
| Acute granuloc… |
84
|
||
| Primary idiopa… |
82
|
||
| Diffuse sclero… |
81
|
 Individual Studies |
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|---|---|
|
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Homo sapiens
|
RNA Expression
Saccharomyces cerevisiae
|
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Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome.
Authors: Woranontee Weraarpachai, Hana Antonicka, Florin Sasarman, Jürgen Seeger, Bertold Schrank, Jill E Kolesar, Hanns Lochmüller, Mario Chevrette, Brett A Kaufman, Rita Horvath,…
Nature genetics 2009 Jul -
A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.
Authors: Ian M Morison, Elisabeth M Cramer Bordé, Emma J Cheesman, Pak Leng Cheong, Andrew J Holyoake, Serge Fichelson, Robert J Weeks, Alexandra Lo, Stefan M K Davies, Sigurd M Wilbanks,…
Nature genetics 2008 Apr
Thought leaders and organizations working on research involving CYCS.
- National Institute of Allergy and Infectious Diseases (NIAID)
- Cambridge University Hospitals NHS Foundation Trust
- National Heart, Lung, and Blood Institute (NHLBI)
- Mayo Clinic
- Assistance Publique - Hôpitaux de Paris
- University of Miami Miller School of Medicine
- Foundation IRCCS Neurological Institute C. Besta
- Smurfit Institute
- Dulbecco-Telethon Institute
- McGill University
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Five-Year Actively Controlled Clinical Trial in New Onset Juvenile Systemic Lupus Erythematosus Nephritis
conditions: Systemic Lupus Erythematosus Nephritis
interventions: cyclophosphamide-prednisone-azathioprine
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Interferon ß-1b Treatment by Cyclical Administration
conditions: Multiple Sclerosis
interventions: Interferon-ß-1b
