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chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
For background information on chemokines, see CXCL1 (MIM 155730). Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chem...
Normal tissues
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| Femur |
100
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| Myometrium |
81
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| Mesenteric lymph nod… |
76
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| Synovial membrane |
72
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| Vomeronasal organ |
68
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| Uterus |
68
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Compounds
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| Tomatidenol |
100
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| Probenecid |
96
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| Aminophylline |
88
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| Dilazep |
84
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| Yohimban-16-carboxyl… |
82
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| Fulvestrant |
80
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 Individual Studies |
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Homo sapiens
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RNA Expression
Mus musculus
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CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling.
Authors: Angélique Levoye, Karl Balabanian, Françoise Baleux, Françoise Bachelerie, Bernard Lagane
Blood 2009 Jun 11 -
CXCL12/CXCR4 signalling in neuronal cell migration.
Authors: Marie-Catherine Tiveron, Harold Cremer
Current opinion in neurobiology 2008 Jun
Thought leaders and organizations working on research involving CXCL12.
- Sekar Kathiresan
- Heribert Schunkert
- Roberto Elosua
- Nilesh J Samani
- Stephen M Schwartz
- National Taiwan University Hospital
- Far Eastern Memorial Hospital
- Tel-Aviv Sourasky Medical Center
- National Institute of Allergy and Infectious Diseases (NIAID)
- Takeda Italia Farmaceutici S.p.A.
- Massachusetts General Hospital
- New York University School of Medicine
- Indiana University School of Medicine
- Weizmann Institute of Science
- Lerner Research Institute
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Role of Chemokines and Proinflammatory Cytokines in Rheumatoid Synovial Pathological Changes
conditions: Rheumatoid Arthritis
interventions: none
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Studies on the Significance of CXCR4-CXCL12 on Leukemic Cells Passing Through"Marrow-Blood Barrier"
conditions: Acute Myelocytic Leukemia ; Acute Lymphocytic Leukemia
interventions: none
Community
Researcher
CINJ/UMDNJ
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