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cathepsin D

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq]

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Data Correlations | 1,642 studies

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Tissues category icon Normal tissues
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Fat body 100 100
Set of fingers 97 97
Epidermis 94 94
Trigeminal ganglion 87 87
Urinary bladder 86 86
Cecum 84 84
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Compounds category icon Compounds
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Meloxicam 100 100
Fulvestrant 96 96
Spironolactone 95 95
Sandoglobulin 92 92
Nystatin A1 90 90
Ethylestrenol 89 89
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Diseases category icon Diseases
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Neuronal ceroid lipo… 100 100
Ischemia 100 100
Primary cutaneous di… 91 91
Streptococcal pneumo… 87 87
Juvenile myopathy, e… 87 87
Transection of spina… 87 87
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Individual Studies

  • OMIM - Congenital disorder

    score: 100100 | Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data

  • Gene expression profile of PDGF-treated neural stem cells

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Gene expression in neural stem cells that were grown in the presence of FGF-2 to that of cells cultured with PDGF-AA or in the absence of growth factor, which induces differentiation.

    Authors: Demoulin Jean-Baptiste, Enarsson Mia, Essaghir Ahmed et al.

    Organization: Universite Catholique de Louvain MEXP un…
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Associated Researchers

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Thought leaders and organizations working on research involving CTSD.

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  • Paul Saftig
  • Jaana Tyynelä
  • Aleksi Haapanen
  • David Strachan
  • Sanna Partanen
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  • National Center for Research Resources (NCRR)
  • Washington University School of Medicine
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  • University of Helsinki
  • University of Oxford
  • Università del Piemonte Orientale A. Avogadro
  • Korea Institute of Radiological and Medical Sciences
  • Massachusetts General Hospital

Clinical Trials | 2 trials

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Community

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View All NextBio Users | 2 people
  • Qiaojuan Jane Su Qiaojuan Jane  Su

    Dir, Scientific Computing

    NextBio

  • Khader Shameer Khader  Shameer

    PhD Student in Prof. R. Sowdhamini's Computational Biology Lab

    National Centre for Biological Sciences - Tata Institute of Fundamental Research

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