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corticotropin releasing hormone

Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length o...

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Data Correlations | 480 studies

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Tissues category icon Normal tissues
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Lateral nuclear grou… 100 100
Placenta 95 95
Vestibular nuclear c… 93 93
Thalamus 86 86
Caudate nucleus 84 84
Ventral tegmental ar… 83 83
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Compounds category icon Compounds
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Zoman 100 100
Methylatropine Nitra… 98 98
Sid 734787 98 98
Pancuronium Bromide 97 97
Hi 6 97 97
Cocaine 96 96
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Diseases category icon Diseases
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Adrenocorticotropic … 100 100
Not getting enough s… 93 93
Aging 83 83
Neuroblastoma of bra… 76 76
Dehydration 75 75
Spinal cord injuries 74 74
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Individual Studies

  • Changes in the course of normal brain aging are sexually dimorphic

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Gene expression profiles were assessed in the hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG) across the lifespan of 63 cognitively intact individuals from 20-99 years old. New perspectives on the global gene changes that are associated with brain a…

    Authors: Berchtold C Nicole, Cribbs H David, Coleman D Paul et al.

    Organization: Institute for Brain Aging Carl W. Cotman…
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Associated Researchers

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Thought leaders and organizations working on research involving CRH.

View All Author iconAuthors
  • Anja Böckmann
  • Lawrence H Price
  • Markus Heilig
  • J M Deussing
  • A Slominski
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Eunice Kennedy Shriver National Institute of Child Health and Human De…
  • National Institute of Mental Health (NIMH)
  • Centre Rene Huguenin
  • Children's Mercy Hospital Kansas City
  • Medical University of South Carolina
View All Affiliations icon Organizations
  • Max Planck Institute of Psychiatry
  • National Institute on Alcohol Abuse Alcoholism
  • University of Crete
  • University of Virginia
  • Butler Hospital

Clinical Trials | 58 trials

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