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cAMP responsive element modulator
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq]
Normal tissues
|
|
||
|---|---|---|---|
| Peripheral blood mon… |
100
|
||
| Adrenal cortex |
99
|
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| Adrenal gland |
95
|
||
| Pericardium |
90
|
||
| Caudate nucleus |
89
|
||
| Subdivision of nucle… |
87
|
Compounds
|
|
||
|---|---|---|---|
| 8-aminohexylamino-ad… |
100
|
||
| Dibutyryl Adenosine … |
93
|
||
| Norepinephrine |
86
|
||
| Cocaine |
82
|
||
| Dextrose |
82
|
||
| Potassium Chloride (… |
79
|
 Individual Studies |
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|---|---|
|
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Homo sapiens
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RNA Expression
Mus musculus
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ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells.
Authors: Josef Bodor, Zoltan Fehervari, Betty Diamond, Shimon Sakaguchi
European journal of immunology 2007 Apr -
Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction.
Authors: Geertje Lewin, Marek Matus, Abhijit Basu, Karin Frebel, Sebastian Pius Rohsbach, Andrej Safronenko, Matthias Dodo Seidl, Frank Stümpel, Igor Buchwalow, Simone König,…
Circulation 2009 Jan 6
Thought leaders and organizations working on research involving CREM.
- ISDIN
- PhotoCure
- University of Connecticut Health Center
- Institut de Génétique et de Biologie Moléculaire et Cellulaire
- University of Rochester School of Medicine and Dentistry
- University of Ljubljana
- German Cancer Research Center
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Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Patients With Skin Type V or IV With Acne Vulgaris
conditions: Acne Vulgaris
interventions: Methyl aminolevulinate (MAL) PDT
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Open Label Extension (OLE) for the Patients Treated in the ISD002-P144-07 Study
conditions: Skin Fibrosis
interventions: P144 cream
