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cholinergic receptor, nicotinic, alpha 4

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been...

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Data Correlations | 932 studies

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Tissues category icon Normal tissues
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Thalamus 100 100
Substantia nigra 98 98
Thyroid gland 94 94
Pancreas 94 94
Epidermis 92 92
Caudate nucleus 92 92
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Compounds category icon Compounds
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Amikin 100 100
Lead, Isotope Of Mas… 87 87
Sodium Pyruvate 86 86
Cobalt, Isotope Of M… 86 86
Retinoic Acid 84 84
Blebbistatin 83 83
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Diseases category icon Diseases
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Epilepsy 100 100
Starvation 100 100
Hepatitis B 86 86
Pseudopelade 79 79
Gonorrhea 77 77
ISM - In situ melano… 76 76
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Individual Studies

  • Mouse Phenotypes - Epilepsy

    score: 100100 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • Heart, liver, muscle and adipose tissue from mice on standard, high calorie, or resveratrol diet

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Male C57BL/6NIA mice at one year of age, mice were fed a Standard Diet every day or Every other day (EOD) as well groups fed a standard diet plus 0.01% or 0.04% resveratrol for the duration of the study. Three separate groups were placed on an High Calorie diet (modified by the addition of hydrogena…

    Authors: Pearson J Kevin, Baur A Joseph, Lewis N Kaitlyn et al.

    Organization: National Institute on Aging, NIH Researc…
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Associated Researchers

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Thought leaders and organizations working on research involving CHRNA4.

View All Author iconAuthors
  • Ortrud K Steinlein
  • Daniel Bertrand
  • S F Berkovic
  • I E Scheffer
  • Wieslaw H Trzeciak
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Taiwan University Hospital
View All Affiliations icon Organizations
  • University of Medical Sciences
  • Hospital for Sick Children
  • University of Oslo
  • University of Colorado
  • Women's and Children's Hospital

Clinical Trials | 1 trial

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