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complement factor B

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes invo...

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Data Correlations | 1,276 studies

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Tissues category icon Normal tissues
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Pericardium 100 100
Mesenteric lymph nod… 81 81
Uterine tube 72 72
Set of pancreatic is… 66 66
Fetal organ 66 66
Vomeronasal organ 62 62
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Compounds category icon Compounds
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Oligodeoxyribonucleo… 100 100
Aids070130 93 93
Haemophilus Influenz… 89 89
Peoniflorin 88 88
Oxypaeoniflora 88 88
Paeonol 85 85
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Diseases category icon Diseases
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Age related macular … 100 100
Non-alcoholic fatty … 100 100
Haemophilus infectio… 67 67
Pseudomonas infectio… 60 60
Serous cystadenoma o… 57 57
N1 54 54
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Individual Studies

  • Normal human monocytes response to Aspergillus fumigatus exposure

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Microarray analysis to explore gene expression in human monocytes infected with Aspergillus conidia as compared with unstimulated monocytes and those stimulated with lipopolysaccharide (LPS).

    Source: NextBio Library/Immune response and infection

  • LPS tolerance in macrophages

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Among the multiple mechanisms that control the intensity and duration of macrophage activation, the development of a state of refractoriness to a second stimulation in cells treated with LPS has long been recognized. Release of inhibitory cytokines and alterations in intracellular signaling pathways…

    Authors: Mages J, Lang R

    Organization: Technical University Munich Institute of…
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Associated Researchers

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Thought leaders and organizations working on research involving CFB.

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  • Gregory S Hageman
  • Bernard Rosner
  • Kylee L Spencer
  • José E Manautou
  • Jonathan L Haines
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Can-Fite BioPharma
  • North Shore Long Island Jewish Health System
View All Affiliations icon Organizations
  • University of Pennsylvania School of Medicine
  • Washington University School of Medicine
  • University of Connecticut
  • Ohio State University
  • University of Alabama - Birmingham

Clinical Trials | 2 trials

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Community

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